No one knows a prescription drug’s side effects like the person taking it.
Make your voice heard.
RxISK is a free, independent drug safety website to help you weigh the benefits of any medication against its potential dangers.

Could it be my meds?
All drugs have side effects, but people often don’t link the effect they are experiencing to starting, stopping, or changing the dose of a drug. RxISK provides free access to information and tools to help you assess the connection between a drug and a side effect.
Get medication harms into your medical record
Our free Healthcare Record Pro Forma is a one page document that you can complete with details of your problem together with an official SNOMED code, and then give it to your doctor.
Explore our RxISK Zones
The RxISK Zones bring together a collection of content from our website about each type of side effect. They are aimed at giving you a good overview of the issue without having to search through lots of material.
Our zones cover suicide, violence, sex and relationships, hair, skin and nails, withdrawal, vision, and fertility.
PSSD Research Fund
Your donations are needed to fund scientific research into post-SSRI sexual dysfunction (PSSD) and other enduring sexual dysfunctions. The aim is to better understand the biology of these conditions and hopefully find treatments.
From The Blog…
MHRA Announces New Warnings for Suicide and PSSD
On 15 October 2026, the UK’s Medicines and Healthcare products Regulatory Agency (MHRA) announced new warnings for SSRI and SNRI antidepressants. These will include a new boxed warning in the patient information leaflet for suicidal thoughts and behaviours, a new patient card, a supporting safety leaflet, and the addition of the term post-SSRI sexual dysfunction…
Continue Reading MHRA Announces New Warnings for Suicide and PSSD
The Troubled Dream of Life
This is the first time RxISK has run 2 posts on the same topic on the same day. Not only that but in addition to the Troubled Dream of Life linking to Drug Induced Loss of Capacity that follows on from this post, Troubled also links to Damnation and Salvation posted on dh.org today. Finally…
Drug Induced Loss of Capacity
Twenty four years ago, after a Panorama program, The Secrets of Seroxat (Paroxetine), the BBC was flooded with nearly 1400 emails, then a new way to communicate, about your experiences on SSRIs. This led to a follow up Panorama program – Emails from the Edge – and then two more follow ups. Your emails outlined…









